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Lung stem cell behavior in development and regeneration
Ahmed R. N. Ibrahim1, Ahmed H. K. El-Hashash2
1PhD, Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 El-Minia, Egypt, Stem Cells, Regenerative Medicine and Developmental Biology, Program, Children's Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California. USA.
2PhD, Stem Cells, Regenerative Medicine and Developmental Biology, Program, Children's Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA.

Article ID: 100001S03AI2015
doi:10.5348/S03-2015-1-RA-1

Address correspondence to:
Ahmed El-Hashash
PhD, Assistant Professor, Stem Cells, Regenerative Medicine and Developmental Biology Program, The Saban Research Institute, Children's Hospital Los Angeles
4661 Sunset Boulevard MS 35
Los Angeles, California, CA 90027
USA
Phone: 001-323-361-2764
Fax: 001-323-361-3613

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How to cite this article
Ibrahim ARN, El-Hashash AHK. Lung stem cell behavior in development and regeneration. Edorium J Stem Cell Res Ther 2015;1:1–13.


Abstract
New data have accumulated on the identification, behavior and cellular properties of embryonic and tissue-specific stem cells over the last decade. The modes of stem cell division, asymmetric versus symmetric, are tightly regulated during development and regeneration. The proper choice of a stem cell to divide asymmetrically or symmetrically has great consequences for development and disease because inappropriate asymmetric division disrupts organ morphogenesis, whereas uncontrolled symmetric division induces tumorigenesis. Therefore, understanding the behavior of lung stem cells could identify innovative solutions for restoring normal morphogenesis and/or regeneration of different organs. In this concise review, we describe different types of lung stem/progenitor cells and mechanisms controlling their proliferation and differentiation as well as recent studies in our laboratory about the mode of division of lung epithelial stem cells. We also compare asymmetric cell division in the lung stem cells with other tissues in different organisms.

Keywords: Asymmetric stem cell division, Differentiation and characterization, Lung stem/progenitor cells, Regeneration of lung stem cells, Types of lung stem cells

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Author Contributions
Ahmed R. N. Ibrahim – Substantial contribution to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ahmed H. K. El-Hashash – Substantial contribution to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Ahmed R. N. Ibrahim et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Ahmed Ragaa Nour Ibrahim is Assistant Professor at the Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt and post-doctoral fellow in at the Department of Surgical Research at Childrens' Hospital Los Angeles, USA. He earned undergraduate degree (Bachelor of Pharmaceutical Sciences) from Faculty of Pharmacy, Minia University, Minia, Egypt and postgraduate degree form (Master of Science) from Hiroshima University, Higashi-Hiroshima, Japan and Doctor of Philosophy from Hiroshima University, Higashi-Hiroshima, Japan. He has published research papers in national and international academic journals and authored books. His research interests include stem cells, regenerative medicine, lung diseases, allergy, immunology, and protein-protein interactions.



Ahmed El-Hashash is Assistant Professor of Stem Cell Biology and Regenerative Medicine at the Department of Surgery at Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, USA. He has completed PhD from Manchester University, UK. He worked as a Senior Biomedical Research Scientist at Mount Sinai School of Medicine of New York University and Children's Hospital Los Angeles (CHLA). He has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine. He is a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM). He has published more than 23 papers in reputed international journals and serving as an editorial board member of repute. Dr. El-Hashash acts as a discussion leader at the prestigious Gordon Research Conference in USA and other international conferences. He is invited to speak at several international conferences in USA, Spain, Egypt and China. He is the author/editor of three internationally distributed books on stem cell and regenerative medicine.